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Agilent 6495B Triple Quad LC/MS with 1260 Infinity II HPLC

Listing #:LS-007128
Brand:Agilent
Model:6495B, G7104C, G7115A, G7116B, G7167A
Availability:In Stock
Condition:Refurbished
Warranty:90 Days
Onsite Installation:Available upon request
In Stock

Agilent 6495B Triple Quad LC/MS with 1260 Infinity II HPLC — iFunnel triple quadrupole with Jet Stream source and a full 1260 Infinity II front end with flexible pump, multisampler, MCT, and DAD. Refurbished and tested by Alliant Scientific.

Description

Agilent 6495B Triple Quad LC/MS with 1260 Infinity II HPLC Overview

This Agilent 6495B Triple Quad LC/MS with 1260 Infinity II HPLC is a complete ultra-sensitive LC/MS/MS system for trace-level quantitation. The 6495B uses Agilent iFunnel technology, which combines a hexabore capillary, a dual-stage ion funnel, and the Jet Stream source to capture many more ions than a conventional triple quadrupole. Agilent reports up to a ten-fold signal improvement over non-iFunnel instruments, with high precision at sub-millisecond dwell times.

The 1260 Infinity II HPLC delivers the chromatography the mass spectrometer needs. Its flexible pump handles pressures up to 800 bar, so the system runs standard HPLC and UHPLC columns, and its multisampler holds up to 6144 samples in microtiter plates. A thermostatted column compartment and a diode array detector complete the front end, which gives analysts UV data alongside the MS/MS results. MassHunter software controls the LC and MS together from one PC.

Laboratories that need low detection limits in difficult matrices use systems like this every day. Pharmaceutical and biotech groups run bioanalysis, DMPK studies, and peptide quantitation, while food safety and environmental laboratories screen for pesticides, mycotoxins, veterinary drugs, and emerging contaminants such as PFAS. Clinical research, toxicology, and contract research organizations also depend on this level of sensitivity and throughput.

This Agilent 6495B Triple Quad LC/MS with 1260 Infinity II HPLC is offered fully refurbished and tested, in working condition, by Alliant Scientific.

Includes:

  • Agilent 6495B Triple Quad LC/MS
      • Agilent Jet Stream (AJS) Source
    • Vacuum Pump(s)
    • Solvent Tray
  • Agilent 1260 Infinity II HPLC System
      • G7104C Flexible Pump
      • G7167A Multisampler
      • G7116B Multicolumn Thermostat (MCT)
      • G7115A DAD WR
  • PC Loaded with Data System
  • 90-Day Warranty

Disclaimer: All brand names and trademarks are the property of their respective owners and are used for identification only. The seller is not authorized by or associated with Agilent. This product has not been reviewed, tested, or certified by Agilent to verify its quality or compatibility with Agilent’s products. Software, if included, is not transferable or upgradable.

Listing last updated: November 2026.

Technical Specifications

Manufacturer Agilent Technologies
Mass Spectrometer 6495B Triple Quadrupole LC/MS with iFunnel technology
Ion Source Agilent Jet Stream (AJS) ESI source
Mass Range m/z 5 to 2,250 (6495A) or m/z 5 to 3,000 (6495B/C)
Acquisition Modes MS1 and MS2 scan, product ion, precursor ion, neutral loss, SIM, MRM (static, dynamic, triggered)
Dynamic MRM Up to 4,000 transitions per method
Software Agilent MassHunter, single point of control for LC and MS
Vacuum System Vacuum pump(s)
HPLC System 1260 Infinity II
Pump (G7104C) Flexible pump, up to 800 bar, flow up to 5 mL/min
Autosampler (G7167A) Multisampler, up to 6144 samples in microtiter plates, up to 600 bar
Column Compartment (G7116B) Multicolumn thermostat
Detector (G7115A) Diode array detector WR, 190 to 950 nm, up to 120 Hz
Data System PC with MassHunter data system
Condition Refurbished and tested
Warranty 90 days

Additional information

Availability

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Condition

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Onsite Installation

Warranty

Key Features

  • iFunnel Technology
    A hexabore capillary and dual-stage ion funnel bring far more ions into the analyzer, which lowers detection limits.
  • Jet Stream Source
    Superheated sheath gas improves desolvation and ion collection for cleaner, stronger signals.
  • Dynamic MRM
    Schedule thousands of transitions in one method for large multiresidue panels.
  • Complete LC Front End
    The 1260 Infinity II gives you gradient pumping, automated injection, column temperature control, and UV detection in one platform.
  • High-Capacity Multisampler
    Holds up to 6144 samples in microtiter plates for long unattended runs.
  • Single Point of Control
    MassHunter runs the LC and the mass spectrometer from the included PC.

Applications

  • Bioanalysis and DMPK
    Drug and metabolite quantitation in plasma, serum, and tissue.
  • Peptide and Protein Quantitation
    Targeted proteomics and biopharma characterization.
  • Food Safety
    Pesticides, mycotoxins, and veterinary drug residues at regulatory limits.
  • Environmental Testing
    PFAS, pharmaceuticals, and other trace contaminants in water and soil.
  • Clinical Research and Toxicology
    Panels for drugs of abuse and biomarkers in complex matrices.

FAQ (Frequently Asked Questions)

Who typically uses a 6495B triple quad?

Pharmaceutical and biotech labs, food safety and environmental testing labs, clinical research groups, and contract research organizations that need very low detection limits.

What does iFunnel technology do?

It captures and focuses more ions from the source, which increases signal and lowers limits of detection.

Does the system include the HPLC?

Yes — the 1260 Infinity II HPLC with flexible pump, multisampler, column thermostat, and diode array detector is included.

What software controls the system?

Agilent MassHunter on the included PC.

Does this system include a warranty?

Yes — it ships with a 90-day warranty.