Description
Quick Answer
The Agilent 6490 Triple Quad LC/MS is a high-sensitivity LC-MS/MS system with iFunnel-enhanced ion transmission, an m/z 5–1,400 mass range, and Agilent Jet Stream source for demanding multi-residue MRM methods. This refurbished unit is fully tested by Alliant Scientific and ships with a 90-day warranty.
Listing last updated: August 2026.
Agilent 6490 Triple Quad LC/MS Overview
This system pairs iFunnel ion optics with the Agilent Jet Stream source to deliver strong sensitivity and reproducibility across demanding sample matrices, from biological fluids to environmental extracts, without the extended mass range (or price) of the 6495B.
At the core of the 6490 is an advanced ion handling design that enhances ion capture and transmission efficiency, enabling detection of compounds at extremely low concentration levels. This increased sensitivity allows analysts to confidently measure trace compounds that are difficult to detect with conventional LC-MS/MS systems.
Agilent 6490 Triple Quad LC/MS system is specifically optimized for quantitative workflows using multiple reaction monitoring (MRM). Its high-speed acquisition capabilities enable accurate monitoring of a large number of transitions within a single run, making it effective for multi-residue and high-throughput analyses. It maintains strong reproducibility and signal stability even when processing demanding matrices such as biological fluids, environmental extracts, or food products, and is fully compatible with fast UHPLC methods — capturing narrow peak widths while maintaining sufficient data density for precise quantitation. Rapid polarity switching allows simultaneous analysis of compounds requiring both positive and negative ionization without extending run time.
An optimized collision cell design improves fragmentation efficiency while reducing background interference, producing cleaner spectra and more reliable identification of target analytes. Combined with electrospray ionization (ESI) and optional multi-mode sources, the platform adapts to a wide range of analytical applications.
Agilent 6490 Triple Quad LC/MS is offered fully refurbished and tested, in working condition by Alliant Scientific.
Includes:
- Agilent 6490 Triple Quad LC/MS
- Jet Stream Source
- Two (2) Vacuum Pumps
- Data System
- 90-Day Warranty
Optional:
- Agilent UHPLC Front End Systems (1260 or 1290 Infinity Series)
- Premium Refurbishment with Extended Warranty
Disclaimer: All brand names and trademarks are the property of their respective owners and are used for identification only. We are not an authorized dealer. Software, if included, is not transferable or upgradable.
