Agilent 6546A Q-TOF LC/MS System with 1260 Infinity II Front End

Key Features

• Accurate-Mass Identification
  High resolution and mass accuracy typically within 1 ppm let analysts assign molecular formulas and separate compounds that share a nominal mass. This is what makes unknown screening and impurity work practical.
• Two Ionization Modes on One Source
  The Dual AJS MultiMode source covers electrospray and APCI. That widens the range of polar and less polar compounds the system can detect without changing instruments.
• Four-Solvent Quaternary Pump
  The pump blends up to four solvents on the fly. Analysts can screen mobile phases and adjust gradients without remixing bottles, which shortens method development.
• Cooled Vialsampler for Overnight Runs
  The sampler holds up to 132 vials and keeps them at a controlled temperature. Sensitive samples stay stable through long unattended sequences.
• Stable Column Temperature
  The multicolumn thermostat operates from 10 °C below ambient to 85 °C. Steady temperature keeps retention times consistent from batch to batch.
• UV Detection Next to the Mass Spectra
  The variable wavelength detector adds a single-wavelength UV trace. It is a simple way to confirm quantitation and spot peaks before reviewing the MS data.
• One Workstation Controls Everything
  MassHunter software on the included data system runs the LC and mass spectrometer together.

Applications

• Pharmaceutical Impurity and Degradant Identification
  Generic drug manufacturers and quality control laboratories identify unknown peaks in stability samples and confirm structures from accurate fragment masses.
• Pesticide Residue Screening in Food
  Food safety and contract testing laboratories screen produce, grain, and honey for hundreds of residues in a single run.
• Forensic and Clinical Toxicology
  Toxicology laboratories run broad drug and metabolite screens on blood and urine, including compounds outside a targeted panel.
• Anti-Doping Analysis
  Sports testing laboratories detect prohibited substances and their metabolites in athlete samples.
• Environmental Water Testing
  Water utilities and environmental laboratories look for pharmaceuticals, industrial chemicals, and pesticide transformation products in surface water and wastewater.
• Food Authenticity and Adulteration
  Laboratories check olive oil, fruit juices, and spices for marker compounds that reveal dilution or substitution.
• Flavor, Fragrance, and Chemical Manufacturing
  Producers confirm raw material identity and investigate off-spec batches.

FAQ (Frequently Asked Questions)

Who typically uses an Agilent 6546A Q-TOF LC/MS system?

Pharmaceutical QC and generic drug laboratories, food safety and contract testing laboratories, forensic and toxicology laboratories, anti-doping laboratories, and environmental and water testing laboratories. The common need is identifying compounds that are not on a targeted list.

What does the VWD add to the mass spectrometer?

It gives a single-wavelength UV trace that runs alongside the accurate-mass data. Analysts use it to confirm quantitation, check peak purity at a chosen wavelength, and keep a familiar UV record for methods that already rely on it.

How many samples can the vialsampler hold?

Up to 132 vials of 2 mL. The cooling unit keeps samples at a controlled temperature during long overnight runs.

Which ionization modes does the source support?

Both electrospray (ESI) and APCI through the Dual AJS MultiMode source. That lets one system handle polar compounds and less polar compounds.

What accuracy and resolution can I expect?

Mass accuracy is typically within 1 ppm. Resolution is 30,000 or better across the mass range and above 60,000 at higher masses, and it holds as the acquisition rate increases.

Which software controls the system?

Agilent MassHunter on the included data system controls both the LC and the mass spectrometer.

Does this system include a warranty?

Yes — it ships with a 90-day warranty.