Description
Quick Answer
Agilent 6495B is a Triple Quad LC/MS system built on Agilent’s iFunnel platform, delivering ultra-trace sensitivity with an extended m/z 5–3,000 mass range for peptide quantitation and demanding multi-residue methods. This refurbished unit includes the Agilent Jet Stream source and is fully tested by Alliant Scientific.
Listing last updated: September 2026.
Agilent 6495B Triple Quad LC/MS Overview
This system delivers ultra-trace sensitivity down to sub-picogram/attogram levels, and its extended m/z 5–3,000 range makes it especially well suited for large peptide fragment work, not just standard small-molecule quantitation.
The Agilent 6495B Triple Quad LC/MS System is a high-performance liquid chromatography–tandem mass spectrometry platform built for laboratories that need maximum sensitivity, wide dynamic range, and reliable quantitation across complex sample types. At its core is Agilent’s iFunnel ion optics design, which improves ion capture and transmission efficiency into the mass analyzer — allowing detection of compounds at extremely low concentrations that are difficult to resolve on conventional LC-MS/MS systems.
The 6495B extends the mass range to m/z 3,000, which makes it a strong fit for large peptide fragment detection alongside standard small-molecule quantitation — a meaningful step up from earlier 6495-series units for labs doing peptide or protein-fragment work. It’s optimized for multiple reaction monitoring (MRM) workflows, with fast acquisition speeds that support large-scale multi-residue and multi-transition methods without sacrificing dwell time or reproducibility.
Paired with the Agilent Jet Stream (AJS) source, the system maintains strong signal stability across demanding matrices — biological fluids, environmental extracts, food and spice matrices — and is fully compatible with fast UHPLC methods, capturing narrow peak widths while preserving data density for accurate quantitation. Rapid polarity switching allows simultaneous positive/negative ionization workflows without extending run time.
Agilent 6495B Triple Quad LC/MS is offered fully refurbished and tested, in working condition by Alliant Scientific.
Includes:
- Agilent 6495B Triple Quad LC/MS
- Agilent Jet Stream (AJS) Source
- Vacuum Pump(s)
- Data System
- 90-Day Warranty
Optional:
- Agilent UHPLC Front End Systems (1260 or 1290 Infinity Series)
- Premium Refurbishment with Extended Warranty
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