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Agilent 6460 Triple Quad LC/MS System with 1260 Infinity Front End
$54,900.00
In Stock
Description
Agilent 6460 Triple Quad LC/MS System with 1260 Infinity Front End
Agilent 6460 Triple Quad LC/MS System with 1260 Infinity Front End is a high-performance analytical platform designed for sensitive, selective, and reproducible quantitative analysis across complex sample matrices. This configuration integrates efficient chromatographic separation with advanced mass spectrometry detection, enabling reliable analysis of trace-level compounds.
The system is engineered to deliver stable gradient performance, precise flow control, and consistent sample introduction, ensuring high-quality chromatographic separations prior to mass analysis. Binary high-pressure solvent mixing supports efficient gradient formation, improving peak resolution and retention time stability across diverse analytical methods. The inclusion of Jet Stream technology enhances ionization efficiency by focusing and heating the nebulized spray, increasing signal intensity and improving sensitivity for low-abundance analytes. This results in stronger signal response and improved detection limits, particularly in demanding analytical environments.
The triple quadrupole mass spectrometer enables highly selective detection using Multiple Reaction Monitoring (MRM), allowing accurate quantification even in samples with significant background interference. Combined with optimized thermal stability and low carryover injection, the system delivers reproducible and reliable results across extended analytical runs.
Overall, the Agilent 6460 LC/MS system provides a strong balance of sensitivity, selectivity, and robustness, making it well suited for pharmaceutical, environmental, food safety, and chemical analysis applications.
This refurbished Agilent 6460 LC/MS System has been fully tested and verified to be in proper working condition by Alliant Scientific.
Includes:
- Agilent 6460 Triple Quad LC/MS
- Jet Stream Source
- Vacuum Pump
- Agilent 1260 Infinity Front End
- Degasser
- Binary Pump
- Autosampler
- TCC
- Data System
- 90 Day Warranty Coverage
Optional:
- Premium refurbishment available with extended warranty options
Disclaimer:Â All brand names and trademarks are the property of their respective owners and are used for identification only. We are not an authorized dealer. Software, if included, is not transferable or upgradable.
Technical Specifications
| Agilent 6460A LC/MS System with 1260 Infinity Front-End | |
| System Type | Triple quadrupole LC/MS system with integrated HPLC front-end |
| Mass Analyzer | Triple quadrupole (QqQ) configuration for quantitative analysis |
| Scan Modes | MRM, SIM, and full scan acquisition |
| Ionization Source | Jet Stream electrospray ionization (ESI) with enhanced thermal focusing |
| Mass Range | Up to m/z ~3000 |
| Sensitivity | Enhanced sensitivity via Jet Stream technology for improved signal intensity |
| Dynamic Range | Wide dynamic range for accurate quantification across concentrations |
| LC Front-End | 1260 Infinity HPLC system with binary gradient capability |
| Flow Rate Range | 0.001 – 10 mL/min |
| Degassing | Integrated vacuum degassing for stable baseline performance |
| Sample Introduction | Automated injection with high precision and low carryover |
| Injection Volume Range | ~0.1 – 100 µL |
| Column Compartment | Thermostatted column compartment (TCC) with controlled temperature |
| Temperature Range | Ambient to ~80°C |
| Automation | Sequence-based automated operation for batch analysis |
| Power Requirements | 100 – 240 V, 50/60 Hz |
Additional information
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Key Features
| Jet Stream Ionization | Enhances ionization efficiency for improved sensitivity and signal response |
| Triple Quadrupole Detection | Provides highly selective quantification using MRM transitions |
| Binary Gradient Precision | Ensures accurate solvent mixing and reproducible separations |
| Low Carryover Autosampling | Improves accuracy and consistency in repeated analyses |
| Stable Baseline Performance | Degassing reduces noise and improves detector stability |
| Thermal Stability | Controlled column temperature improves retention time reproducibility |
| Trace-Level Detection | Capable of detecting low-abundance compounds in complex matrices |
| High-Throughput Capability | Supports automated batch processing for efficient workflows |
Applications
| Pharmaceutical LC/MS Analysis | Quantification of APIs, impurities, and metabolites at trace levels |
| Bioanalytical Testing | Analysis of drugs and biomarkers in plasma and biological samples |
| Environmental Testing | Detection of pesticides, pharmaceuticals, and contaminants in water and soil |
| Food Safety Analysis | Identification of residues, additives, and contaminants in food products |
| Toxicology Screening | Detection of drugs, toxins, and unknown compounds |
| Chemical and Industrial Analysis | Characterization of complex mixtures and trace-level compounds |
Frequently Asked Questions (FAQ)
| What is the benefit of Jet Stream ionization? | Jet Stream technology improves ionization efficiency by applying thermal focusing, resulting in increased sensitivity and stronger signal intensity. |
| How does triple quadrupole technology improve quantification? | It uses sequential mass filtering to isolate specific ion transitions, reducing interference and improving accuracy in complex samples. |
| What is MRM and why is it important? | MRM monitors predefined precursor-to-product ion transitions, allowing highly selective and sensitive detection of target compounds. |
| What types of compounds can be analyzed with this system? | The system can analyze pharmaceuticals, environmental contaminants, food residues, metabolites, and various organic compounds. |
| How does the LC front-end improve MS performance? | The HPLC system separates compounds before MS detection, reducing matrix interference and enhancing measurement accuracy. |
| Is this system suitable for trace-level analysis? | Yes, it is designed for detecting and quantifying compounds at very low concentrations in complex matrices. |
| What factors impact reproducibility in LC/MS systems? | Stable flow rates, consistent injection volumes, controlled temperature, and efficient ionization all contribute to reproducible results. |
| Can this system support high-throughput workflows? | Yes, automated sampling and sequence operation allow efficient batch processing in high-throughput laboratories. |
