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Agilent 6546 LC/Q‑TOF Mass Spectrometer with Agilent 1290 Infinity II Front End

Listing #:LS-004822
Brand:Agilent
Model:6546A, G7116B, G7117B, G7120A, G7167B
Availability:In Stock
Condition:Refurbished
Warranty:90 Days
Onsite Installation:Available upon request
$149,500.00
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Agilent 6546 QTOF Mass Spectrometer with Agilent 1290 Infinity II Front End — accurate-mass Q-TOF with a 1300 bar UHPLC front end and 240 Hz diode array detector for high-throughput identification and screening. Refurbished and tested by Alliant Scientific.

Description

This Agilent 6546 QTOF with 1290 Infinity II Front End is a high-throughput accurate-mass system for laboratories that screen large sample sets and need fast, confident identification. The Agilent 6546 QTOF keeps its resolution above 30,000 across the mass range, and above 60,000 at higher masses, even at fast acquisition rates. That combination lets analysts separate compounds with nearly identical masses and assign molecular formulas from accurate fragments.

The 1290 Infinity II front end is what makes the system fast. The binary pump delivers up to 1300 bar at flows to 2 mL/min, so it runs sub-2 µm columns and short gradients, and its low delay volume keeps runs tight. The multisampler holds up to 16 microtiter plates, or 6144 samples, and a sample thermostat keeps them cool during long sequences. A multicolumn thermostat stabilizes retention times, and a diode array detector records UV data at up to 240 Hz beside the mass spectra.

Contract research and testing organizations use this kind of system for high-volume work where turnaround time decides the contract. Pharmaceutical groups run it for drug metabolism studies and metabolite identification, and for extractables and leachables testing of packaging and medical devices. Environmental laboratories use it for non-target PFAS and contaminant screening, and food laboratories rely on it for authenticity testing of olive oil, honey, and juices. Forensic toxicology laboratories screen blood and urine for unknown drugs, and biotech and nutrition companies use it for lipid and metabolite profiling.

This Agilent 6546 QTOF Mass Spectrometer with 1290 Infinity II front end is offered fully refurbished and tested, in working condition, by Alliant Scientific.

Includes:

  • Agilent 6546 QTOF Mass Spectrometer
    • G1958-65271 Jet Stream (AJS) Dual Spray ESI Source
  • Agilent 1290 Infinity II HPLC System
    • G7120A High-Speed Pump
    • G7167B Multisampler
      • G7167-60101 Sample Thermostat
    • G7116B Multicolumn Thermostat (MCT)
    • G7117B Diode Array Detector (DAD)
  • G3215A Mass Spectrometer Bench
  • MS40+ Rotary Vane Roughing Pump
  • Dell PC with Windows 11 Pro and Data System
  • 90-Day Warranty

Compare Agilent 6546 Systems

Compare this system with the Agilent 6546A Q-TOF LC/MS System with 1260 Infinity II Front End, which pairs the same mass spectrometer with a variable wavelength detector at a lower entry point.

Disclaimer: All brand names and trademarks are the property of their respective owners and are used for identification only. The seller is not authorized by or associated with Agilent. This product has not been reviewed, tested, or certified by Agilent to verify its quality or compatibility with Agilent’s products. Software, if included, is not transferable or upgradable.

Listing last updated: November 2026.

Technical Specifications

Manufacturer Agilent Technologies
Mass Spectrometer 6546 LC/Q-TOF (G6546A)
Mass Analyzer Quadrupole, collision cell, time-of-flight (TOF)
Ion Source Electrospray (ESI)
TOF Mass Range m/z 20 to 10,000
Mass Resolution 30,000 or better across the range; above 60,000 at higher masses
Mass Accuracy Typically within 1 ppm
Acquisition Rate Up to 50 spectra per second
Software MassHunter, on the included data system
Vacuum System MS40+ rotary vane roughing pump
LC System 1290 Infinity II UHPLC
Pump (G7120A) Binary pump, up to 1300 bar at 0 to 2 mL/min, ramping to 800 bar at 5 mL/min; integrated degasser
Autosampler (G7167B) Multisampler, up to 16 microtiter plates (6144 samples), 0 to 20 µL or 0 to 100 µL injections at 1300 bar
Sample Thermostat (G7167-60101) Cools samples in the multisampler
Column Compartment (G7116B) Multicolumn thermostat, from 10 °C below ambient to 85 °C
Detector (G7117B) Diode array detector, 190 to 640 nm, up to 240 Hz, 8 signals
Data System Dell PC with Windows 11 Pro
Condition Refurbished and tested
Warranty 90 days

Additional information

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Key Features

  • 1300 bar UHPLC Pump
    The binary pump runs sub-2 µm columns and short gradients, and its low delay volume keeps peaks sharp. That shortens run times without losing separation.
  • High-Capacity Multisampler
    It holds up to 16 microtiter plates, or 6144 samples, with a sample thermostat that keeps them cool through long sequences.
  • Stable Resolution at Speed
    The Q-TOF holds 30,000 or better across the mass range, and above 60,000 at higher masses, at fast scan rates. Analysts can separate compounds with nearly identical masses in a single run.
  • 240 Hz Diode Array Detector
    The detector records UV spectra fast enough to follow the narrow peaks UHPLC produces, and it runs beside the mass spectra.
  • Stable Column Temperature
    The multicolumn thermostat operates from 10 °C below ambient to 85 °C, so retention times stay consistent from batch to batch.
  • Complete System Setup
    The mass spectrometer bench, MS40+ roughing pump, and Windows 11 data system with MassHunter ship with the system.

Applications

  • Drug Metabolism and Metabolite Identification
    Pharmaceutical groups use accurate-mass fragments to identify metabolites quickly.
  • Extractables and Leachables
    Laboratories identify unknown compounds in packaging and medical device extracts.
  • Non-Target PFAS and Contaminant Screening
    Environmental laboratories flag unexpected compounds in water and soil.
  • Food Authenticity
    Marker compounds reveal adulteration in olive oil, honey, and juices.
  • Forensic Toxicology Screening
    Broad drug screens of blood and urine cover compounds outside a targeted panel.
  • Lipid and Metabolite Profiling
    Biotech and nutrition companies run high-volume profiling of large sample sets.
  • Contract Testing
    Testing organizations use the fast cycle times to meet tight turnaround on large batches.

FAQ (Frequently Asked Questions)

Who typically uses an Agilent 6546 QTOF system?

Contract testing organizations, pharmaceutical groups, environmental and food laboratories, forensic toxicology laboratories, and biotech and nutrition companies that screen large sample sets.

What does the 1290 Infinity II front end add?

UHPLC speed: a 1300 bar pump, a multisampler for up to 6144 samples, a column thermostat, and a 240 Hz diode array detector.

How many samples can the multisampler hold?

Up to 16 microtiter plates, which is 6144 samples. A sample thermostat keeps them cool.

What mass range does the 6546 cover?

m/z 20 to 10,000.

What is included with the system?

The mass spectrometer, the 1290 Infinity II modules, a mass spectrometer bench, an MS40+ roughing pump, and a Dell PC with Windows 11 Pro and the data system.

Which software controls the system?

Agilent MassHunter on the included data system.

Does this system include a warranty?

Yes — it ships with a 90-day warranty.