Agilent 6550 iFunnel Q-TOF LC/MS

• Analyzer Type: Quadrupole Time‑of‑Flight (Q‑TOF)
• Technology: Agilent iFunnel Ion Source with Jet Stream ESI
• Mass Range:
  • MS: m/z 100–10,000
  • Extended Range: m/z 50–1,700 or up to 3,200 (mode‑dependent)
• Quadrupole Mass Range: Up to m/z 4,000

Resolution & Mass Accuracy

• Resolving Power:

  • 25,000 FWHM at m/z 322

  • 42,000 FWHM at m/z 2,722

• Mass Accuracy (MS):
  • <1 ppm RMS with internal mass correction
• Mass Accuracy (MS/MS):
  • <2 ppm RMS
• Mass Stability: <1 ppm over wide temperature ranges

Sensitivity & Dynamic Range

• MS Sensitivity:
  • 1 pg reserpine, S/N ~1,000:1
• MS/MS Sensitivity:
  • 1 pg reserpine, S/N up to ~4,500:1 (maximum sensitivity mode)
• Dynamic Range: Up to 5 orders of magnitude (in‑spectrum)

Speed & Acquisition

• Acquisition Rate:
  • Up to 50 spectra/second (MS and MS/MS)
• Polarity Switching: ~1.5 seconds full cycle
• Scan Modes:
  • MS
  • MS/MS (DDA and targeted)
  • All Ions MS/MS
  • Targeted accurate‑mass analysis

Ionization & Interfaces

• Standard Source: Agilent Jet Stream ESI with iFunnel
• Optional Sources: APCI, Multimode (ESI/APCI), GC‑APCI
• LC Compatibility: Agilent 1260 & 1290 Infinity Series, UHPLC

Vacuum & Electronics

• Flight Tube: INVAR‑stabilized TOF for thermal stability
• Digitizer: 4 GHz high‑speed digitizer
• Vacuum System: High‑efficiency turbo molecular pumping optimized for Q‑TOF performance

Software

• Control & Analysis: Agilent MassHunter Workstation
• Capabilities:
  • Accurate‑mass MS & MS/MS
  • Molecular formula generation
  • Compound profiling and identification
  • Quantitative and qualitative workflows

Typical Applications

• Metabolomics & metabolite identification
• Proteomics and targeted proteomics
• Biopharmaceutical & pharmaceutical analysis
• Food safety testing
• Forensics & toxicology screening
• Environmental analysis