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Agilent 6546 LC/Q-TOF

Listing #:LS-004824
Brand:Agilent
Model:6546
Availability:In Stock
Condition:Refurbished
Warranty:90 Days
Onsite Installation:Available upon request
$94,000.00
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Agilent 6546 LC/Q-TOF — a high-resolution, accurate-mass Q-TOF mass spectrometer with >30,000 FWHM resolution and Dual AJS MultiMode ionization. Refurbished and tested by Alliant Scientific.

Listing last updated: September 2026

Description

Agilent 6546 LC/Q-TOF Overview

The Agilent 6546 LC/Q-TOF (G6546A) is a high-resolution, accurate-mass quadrupole time-of-flight mass spectrometer for liquid chromatography workflows. It resolves ions to at least 30,000 FWHM across the mass range, rising above 60,000 at higher masses, independent of acquisition rate or intensity.

Mass accuracy typically stays better than 1 ppm with minimal drift over long sequences. The quadrupole isolates precursor ions across m/z 20 to 4,000, and the TOF analyzer records a mass range of m/z 20 to 10,000.
Acquisition speed ranges from 3 Hz in full-scan mode up to 30 Hz in targeted MS/MS and Q-RAI (Quadrupole Resolved All Ions) acquisition, without trading off resolution at higher speeds. In-spectrum dynamic range exceeds five orders of magnitude, and isotopic fidelity stays within 5%. Ionization uses a Dual AJS MultiMode source, combining ESI and APCI in a single source. A capillary gate-valve allows cleaning the capillary and accessing the ion source without venting the system, reducing instrument downtime during routine maintenance.

This Agilent 6546 LC/Q-TOF is offered fully refurbished and tested, in working condition, by Alliant Scientific.

Includes:

  • Agilent 6546 LC/Q-TOF Mass Spectrometer (G6546A)
    • Dual AJS MultiMode Source (ESI+APCI)
    • Data System
    • Roughing Pump
  • 90-Day Warranty

Disclaimer: All brand names and trademarks are the property of their respective owners and are used for identification only. We are not an authorized dealer. Software, if included, is not transferable or upgradable.

Looking for an LC Front End?

Browse our full HPLC inventory to pair with this system, or see our LC-MS inventory for other configurations.

Listing last updated: September 2026.

Technical Specifications

Manufacturer Agilent Technologies
Model 6546 LC/Q-TOF (G6546A)
Ion Source Dual AJS MultiMode (ESI+APCI)
Quadrupole Isolation Range m/z 20 to 4,000
TOF Mass Range m/z 20 to 10,000
Mass Resolution (FWHM) > 30,000 at m/z 118; > 60,000 at m/z 2,722, independent of acquisition rate
Mass Accuracy < 0.8 ppm RMS (MS); < 2 ppm RMS (MS/MS)
Acquisition Rate 3 to 30 spectra/second
In-Spectrum Dynamic Range Exceeds 5 orders of magnitude
Isotopic Fidelity < 5%
Sensitivity S/N > 500:1 RMS, 1 pg reserpine on column
Maintenance Access Capillary gate-valve, vent-free ion source/inlet access
Software Agilent MassHunter
Condition Refurbished and tested
Warranty 90 days

Additional information

Availability

Brand

Condition

Model

Onsite Installation

Warranty

Key Features

  • High-Resolution Accurate Mass
    Resolution greater than 30,000 FWHM, rising above 60,000 at higher masses, independent of acquisition rate.
  • Wide Dynamic Range
    In-spectrum dynamic range exceeds five orders of magnitude, detecting trace analytes alongside high-abundance compounds.
  • Fast Acquisition Without Resolution Tradeoff
    Acquisition speeds from 3 Hz (full scan) to 30 Hz (MS/MS) while maintaining resolution.
  • Dual AJS MultiMode Source
    Combines ESI and APCI ionization in a single source.
  • Vent-Free Maintenance
    Capillary gate-valve allows cleaning and ion source access without venting the system.
  • High Isotopic Fidelity
    Isotope ratio accuracy within 5%, supporting confident compound identification.

Applications

  • Metabolomics Research
    High-resolution, accurate-mass profiling of complex biological samples.
  • Food Safety & Authenticity Screening
    Concurrent target and suspect screening for contaminants and adulterants.
  • Environmental Analysis
    Non-target screening of environmental contaminants at trace levels.
  • Molecular Diagnostics & Proteomics
    Detailed molecular characterization for research applications.

FAQ (Frequently Asked Questions)

What mass resolution does the 6546 Q-TOF achieve?

Greater than 30,000 FWHM at m/z 118, rising above 60,000 at m/z 2,722, independent of acquisition rate.

What ionization source does this system use?

A Dual AJS MultiMode source, combining ESI and APCI ionization.

Can I perform maintenance without venting the system?

Yes — a capillary gate-valve allows cleaning the capillary and accessing the ion source without venting.

Does this listing include an LC front end?

No — this is the mass spectrometer only. See our HPLC inventory to pair a front end with this system.

Does this unit include a warranty?

Yes — this unit ships with a 90-day warranty.