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Description
Agilent 6430 Triple Quad LC/MS Overview
The Agilent 6430 Triple Quad LC/MS is a proven, high-performance mass spectrometry platform built for laboratories that demand accurate quantification, consistent sensitivity, and reliable daily operation. Designed to handle complex analytical workflows, this LC-MS/MS system delivers precise, repeatable results at trace levels, even when working with challenging sample matrices. Its triple quadrupole architecture enables highly selective monitoring of target compounds, making it an excellent choice for labs focused on quantitative analysis and regulatory testing.
What sets the 6430 apart is its ability to keep pace with modern UHPLC separations. With ultra-fast data acquisition and rapid polarity switching, the system captures sharp chromatographic peaks without sacrificing data quality. Whether you’re analyzing a handful of compounds or running multi-residue methods, it provides the speed and stability needed for high-throughput environments. The platform also supports dynamic MRM workflows, allowing you to monitor large compound panels efficiently within a single run.
Agilent 6430A Triple Quad LC/MS is offered fully refurbished and tested, in working condition.
Includes:
- Agilent 6430A Triple Quad LC/MSÂ
- ESI Source
- Vacuum Pump
- Dell PC with Windows 11 Pro and Data System
- 90-Day Warranty
Optional:
- Agilent UHPLC Front End Systems (1260 or 1290 Infinity Series)
- Premium Refurbishment with Extended Warranty
Disclaimer: All brand names and trademarks are the property of their respective owners and are used for identification only. We are not an authorized dealer. Software, if included, is not transferable or upgradable.
Technical Specifications
| General | |
|---|---|
| Instrument Type | Liquid Chromatography–Tandem Mass Spectrometry (LC‑MS/MS) |
| Model | Agilent 6430 (G6430A) |
| Mass Analyzer | Triple Quadrupole (QQQ) |
| Ionization Source | Electrospray Ionization (ESI) |
| Application Range | Trace-level quantitative analysis of small molecules in complex matrices |
| Mass Spectrometer Performance | |
| Mass Range | m/z 5 – 2250 |
| Scan Speed | Up to 5,200 u/sec |
| Sensitivity | Picogram-level detection (compound dependent) |
| Polarity Switching | ≤ 30 ms |
| Minimum Dwell Time | 1 ms |
| Resolution | ~0.5 Da (manual), ~0.7 Da (autotune) |
| MRM / Quantitative Performance | |
| Acquisition Mode | Multiple Reaction Monitoring (MRM), Dynamic MRM |
| Total MRM Transitions | Up to ~19,800 |
| Dynamic MRM | Up to ~4,000 time-scheduled transitions |
| Quantitation Capability | High-sensitivity multi-analyte quantitation |
| Data Acquisition Speed | Optimized for UHPLC narrow peak analysis |
| Collision Cell | |
| Type | High-pressure hexapole collision cell |
| Function | Efficient ion fragmentation for MS/MS analysis |
| Collision Gas | Nitrogen (typical) |
| LC Compatibility | |
| Supported Systems | Agilent 1200 / 1260 / 1290 HPLC & UHPLC |
| UHPLC Compatibility | Optimized for sub-2 µm particle separations |
| Peak Handling | Captures narrow UHPLC peaks with high data density |
| Software & Control | |
| Software | Agilent MassHunter Workstation |
| Functionality | Data acquisition, processing, method development, reporting |
| Automation | Integrated instrument control and sequence automation |
| Physical | |
| System Configuration | Modular LC-MS system |
| Footprint | Benchtop mass spectrometer with external LC stack |
| Maintenance Access | Front-access service design |
| Build | Durable modular architecture for routine laboratory use |
Additional information
| Availability | |
|---|---|
| Brand | |
| Condition | |
| Model | |
| Onsite Installation | |
| Warranty |
Key Features
-
High-Sensitivity Quantification
Detect and quantify trace-level compounds with excellent precision, even in complex sample matrices. -
Triple Quadrupole (QQQ) Technology
Delivers superior selectivity and accuracy using advanced MS/MS workflows for targeted analysis. -
Dynamic MRM Capability
Efficiently monitors large panels of analytes by scheduling transitions, maximizing throughput without sacrificing data quality. -
Fast UHPLC Compatibility
Designed to handle narrow chromatographic peaks with rapid data acquisition and minimal signal loss. -
Ultra-Fast Polarity Switching
Seamlessly alternates between positive and negative ion modes, reducing analysis time and improving efficiency. -
Short Dwell Times for High Throughput
Captures more data points per peak, ensuring reliable quantitation in high-speed methods. -
Optimized Ion Optics & Collision Cell
Enhances ion transmission and fragmentation for consistent, high-quality MS/MS results. -
MassHunter Software Integration
Simplifies instrument control, data acquisition, and method development with a user-friendly interface. -
Robust, Reliable Design
Built for routine laboratory use with stable performance and minimal downtime.
Applications
-
Pharmaceutical & Bioanalysis
Drug quantification, metabolite analysis, and pharmacokinetic studies. -
Environmental Testing
Detection of pesticides, pollutants, and contaminants in water, soil, and air samples. -
Food Safety & Agriculture
Multi-residue screening for pesticides, toxins, and chemical residues. -
Clinical & Biomarker Research
Quantification of biomarkers in biological samples for diagnostic and research use. -
Proteomics & Metabolomics
Targeted analysis of peptides, proteins, and small-molecule metabolites. -
Contract Testing Laboratories
High-throughput, routine testing with consistent and reproducible results.
Start Guide – Agilent 6430 Triple Quad LC/MS
FAQ (Frequently Asked Questions)
What is the Agilent 6430 LC/MS used for?
The Agilent 6430 is used for highly sensitive quantitative analysis of chemical compounds in complex samples, commonly across pharmaceutical, environmental, and food testing labs.
The Agilent 6430 is used for highly sensitive quantitative analysis of chemical compounds in complex samples, commonly across pharmaceutical, environmental, and food testing labs.
What type of mass spectrometer is the 6430?
It is a triple quadrupole LC-MS/MS system designed for targeted quantification using MRM (Multiple Reaction Monitoring).
It is a triple quadrupole LC-MS/MS system designed for targeted quantification using MRM (Multiple Reaction Monitoring).
Is the Agilent 6430 suitable for UHPLC systems?
Yes, the system is optimized for UHPLC workflows and can accurately capture fast, narrow chromatographic peaks.
Yes, the system is optimized for UHPLC workflows and can accurately capture fast, narrow chromatographic peaks.
What makes dynamic MRM useful?
Dynamic MRM improves efficiency by only monitoring specific analytes during their expected retention times, allowing more compounds to be analyzed in a single run.
Dynamic MRM improves efficiency by only monitoring specific analytes during their expected retention times, allowing more compounds to be analyzed in a single run.
What ion source does the Agilent 6430 use?
It typically uses an Electrospray Ionization (ESI) source, which is ideal for analyzing a wide range of compounds.
It typically uses an Electrospray Ionization (ESI) source, which is ideal for analyzing a wide range of compounds.
Is this system good for high-throughput labs?
Yes, its fast scan rates, rapid polarity switching, and high MRM capacity make it well-suited for high-throughput workflows.
Yes, its fast scan rates, rapid polarity switching, and high MRM capacity make it well-suited for high-throughput workflows.
Can the Agilent 6430 analyze multiple compounds simultaneously?
Yes, it can monitor thousands of MRM transitions, allowing for comprehensive multi-analyte analysis in one run.
Yes, it can monitor thousands of MRM transitions, allowing for comprehensive multi-analyte analysis in one run.
